Apexification - Management of Open Apex Using Mineral Trioxide Aggregate (MTA) and Platelet Rich Fibrin (PRF): Case Reports

Abstract Apexification is an endodontic procedure to manage immature teeth with non-vital pulp and open apex. It promotes the formation of a calcific barrier at the root apex. These case reports highlight the successful apexification of a maxillary central incisor using mineral trioxide aggregate (MTA) and platelet-rich fibrin (PRF). MTA was used as an apical barrier material which have excellent biocompatibility and sealing properties. while PRF, is used as a biocompatible scaffold that enhanced healing and regeneration. The combined approach ensured predictable outcomes, including apical closure, periapical healing, and preservation of tooth structure. This method demonstrates the efficacy of MTA and PRF as synergistic materials in apexification, offering improved prognosis in challenging cases.