THE CARDIOVASCULAR BENEFITS OF ANTI-OBESITY MEDICATIONS: A GAME-CHANGER IN HEART HEALTH

THE CARDIOVASCULAR BENEFITS OF ANTI-OBESITY MEDICATIONS: A GAME-CHANGER IN HEART HEALTH Dr. Imran Aslam Ph.D. Research Assistant & Assistant Professor, Department of Pharmacology Samarkand State Medical University E-mail: [email protected] Dr. Muhammad Kalim Raza Assistant professor, Samarkand State Medical University, Samarkand, Uzbekistan Dr. Ayesha Ashraf Assistant Professor, Department Histology/Cytology/Embryology Samarkand State Medical University E-mail: [email protected] Dr. Vishal Chauhan Assistant Professor, Department Histology/Cytology/Embryology Samarkand State Medical University E-mail: [email protected] https://doi.org/10.5281/zenodo.15161116 Abstract: Obesity is a significant global health challenge that increases the chance of developing cardiovascular disorders (CVDs), including heart failure, coronary artery disease, and hypertension. Traditional weight-loss methods often yield limited success, prompting the need for pharmacological interventions. Anti-obesity medications (AOMs) have emerged as effective tools for not only weight reduction but also improving cardiovascular health. This article explores the cardiovascular benefits of AOMs, including their role in lowering blood pressure, improving lipid profiles, reducing inflammation, and enhancing insulin sensitivity. Clinical trials, such as the SELECT and LEADER studies, provide strong evidence that medications like semaglutide, liraglutide, and tirzepatide significantly reduce major cardiovascular events. While AOMs offer promising heart health benefits, they should be integrated into a comprehensive lifestyle approach. This review highlights the transformative impact of anti-obesity medications in reducing cardiovascular risks and improving overall well-being. Keywords: Anti-obesity medications, cardiovascular health, obesity, weight loss, hypertension, lipid profile, insulin sensitivity, GLP-1 receptor agonists, cardiovascular disease prevention, metabolic health.