Formulation and Evaluation of A Novel in Situ Gel of Moxifloxacin Drug

The present work describes the formulation and evaluation activated of an ophthalmic delivery system of ananti-bacterial agent- Moxifloxacin. Sodium alginate was used as the gelling agent for Ion activated in situgel, Polyacrylic acid (Carbopol- 934) was used as the gelling agent for pH-triggered in situ gel andPoloxamer was used as the gelling agent for temperature activated in situ gel in combination with HPMC K4M which acted as a viscosity enhancing agent. The evaluated for determination of visual appearance, clarity,pH and Drug Content, In vitro gelation studies, Rheological studies, In vitro drug release study, antimicrobialefficacy Studies, Ocular irritation studies, Sterility testing, Stability studies. Cumulative percent release of86.89 %, 63.23 % and 76.37 %, was observed for optimized formulations