A new neonatal and paediatric TCI theory proposal. Second Part: Algorithm and software construction

The first aim of the second part of the new PK/PD software for TCI Driven Anaesthesia in Neonates, Toddlers and Elderly patients’ “Proposal”, is to give details about the speculative theoretical and applicative mathematical pathways that led us to develop a new algorithm and build up the applicative software. The second aim is to explain and demonstrate the theory applicability to practical use. The final intent is to describe the applicative software, and which is the line of speculations that lead us to choose and decide the compulsory covariate to be use in the development of the theory confirmation. The principles of the theory proposal starts from the definition of new covariate theory values and hypothetic values of “Total Anaesthesia Live Drug Detection and Elimination ” driven by a different pharmacological point of view; a new mathematical equation has been propose and the first consequence of such equation is that “Creatinine or Drug Clerance” could not to be only indexed starting from referred standard concepts , for example, to renal or hepatic elimination of anaesthetic drugs, but must be considered a much more complex event when we speculate about “Dynamic Cells Growth Systems” ,(Neonates , Toddlers, Elderly subjects), and not “Static Cells Growth Systems” as we can consider subjects ranging from 30 kgs weight up to 70 years of age, when a “Rapid Cells Decay Slope Curve” starts in compulsory mode.