Antibacterial and Antifungal Cream of Papaya Seed: A Critical Review of Formulation and Evaluation

Natural plant-based products have gained significant attention in pharmaceutical research due to their potential therapeutic properties. This study focuses on the formulation and evaluation of an antibacterial and antifungal cream derived from papaya (Carica papaya) seeds. Papaya seeds are known to contain bioactive compounds such as alkaloids, flavonoids, and phenolic compounds, which exhibit antimicrobial properties. The project involves the extraction of active compounds from papaya seeds using appropriate solvents, followed by the formulation of a topical cream. The cream is then evaluated for its physicochemical properties, stability, and antimicrobial efficacy against bacterial strains like Staphylococcus aureus and Escherichia coli, as well as fungal strains like Candida albicans and Aspergillus niger. Standard antimicrobial testing methods, such as agar well diffusion, are employed to determine the cream’s effectiveness.