The Prevalence of Methicillin Resistant Staphylococcus Aureus (MRSA) and its Antimicrobial Susceptibility Pattern at Tertiary Care Hospital

Background: Staphylococcus aureus is a very common human pathogen isolated from various clinical specimens. Staphylococcusaureus can cause various infectious diseases like endocarditis, skin and soft tissue infections, osteomyelitis, pneumonia andbacteremia. Methicillin resistant Staphylococcus aureus (MRSA) can cause a major trouble mostly in tertiary care center. Thepresent study is aimed to determine the prevalence of Methicillin Resistant Staphylococcus aureus (MRSA) and its antimicrobialsusceptibility pattern at Tertiary Care Hospital, Vadodara. Material and Methods: Present study was conducted from October 2023 to April 2024 at tertiary care hospital, Vadodara. Total1127 clinical specimens were tested for the study. The isolates were identified as per laboratory standard protocol including staining, colony morphology & biochemical reactions. All isolates were subjected to antibiogram study by modified Kirby Bauer disk diffusion method. Among 1127 clinical specimens, 361 Staphylococcus aureus were isolated and tested for MRSA by Cefoxitindisc diffusion test. Results: Among 361 Staphylococcus aureus isolates, 159 were positive for MRSA. Overall prevalence rate for MRSA isolates was44.04%. Maximum number of MRSA was isolated in Orthopedic ward (53, 33.33%), Surgery ward (39, 24.52%), Intensive CareUnit (28, 17.61%), Medicine ward (17, 10.69%) Pediatric ward (15, 9.43%). Maximum MRSA isolated from Pus and swab (81,50.94%) followed by Urine (36, 22.64%), Blood (27, 16.98%). MRSA were most sensitive to Vancomycin (159, 100%) followedby Teicoplanin (149, 93.71%), Linezolid (142, 89.30%), Clindamycin (71, 44.65%) and least sensitive to Ciprofloxacin (29,18.23%) followed by Erythromycin (42, 26.41%) and Gentamycin (62, 38.99). Conclusion: Prevalence of MRSA in our study is 44.04%, which are multidrug resistance though Vancomycin, Linezolid andTeicoplanin are still effective treatment option. Screening of MRSA and their antibiogram is very essential for early detection ofMRSA and for management of the condition.