Design And Characterization of Buccoadhesive Drug Delivery System

The study demonstrated the feasibility of using a buccal patch system for sustained Metoprolol Succinate release, with F5 being the most optimized patch. The polymer ratio plays a crucial role in determining release characteristics and mechanical performance. The optimal combination of HPMC K4M and ethyl cellulose offers improved patient compliance and sustained therapeutic effect. The release of Metoprolol Succinate from patches over 10 hours is influenced by polymer composition, with formulations with higher ethyl cellulose content showing slower drug release, while higher HPMC K4M content shows faster release.