Development And Evaluation of Polyherbal Ointment Containing Tridex Procumbens

The increasing demand for natural wound care products has led to the exploration of polyherbal formulations that combine the therapeutic benefits of multiple medicinal plants. This study aimed to develop and evaluate a polyherbal ointment containing ethanolic extracts of Tridax procumbens, Ocimum sanctum (Tulsi), Curcuma longa (Turmeric), and Azadirachta indica (Neem) — all renowned for their antimicrobial, anti-inflammatory, antioxidant, and wound healing properties. The ointment was formulated using a standard ointment base and subjected to comprehensive evaluation, including physicochemical parameters, antimicrobial efficacy, and stability studies. The formulated ointment exhibited desirable physical properties such as smooth texture, uniformity, acceptable pH, excellent spreadability, and good extrudability. In antimicrobial testing, the polyherbal ointment demonstrated significant zones of inhibition against Staphylococcus aureus, Escherichia coli, and Candida albicans, indicating broad-spectrum antimicrobial activity. Stability studies confirmed that the formulation retained its physical, chemical, and therapeutic properties under varying storage conditions. These findings highlight the potential of this polyherbal ointment as a safe, effective, and economical alternative to synthetic wound care products, offering multi-faceted benefits for wound healing through the synergistic action of bioactive phytoconstituents.