Perspective Impact of Gelling Agents on the Permeation Behavior for the Topical Delivery of Itraconazole Gel

Itraconazole is a broad spectrum anti-fungal agent which is used to treat various type of antifungal infections. Itraconazole can be given orally but it has side effects such as hepatotoxicity, kidney damage and reproductive issues, so if it is used topically then it has less side effects as compare to its oral administration. Topical administration of Itraconazole ensures site specific delivery for its high permeability that will help to avoid tissue toxicity. Gums and polymers are abundant in nature and come from a variety of marine, microbial, and plant sources and also can be synthesized. Their functional and physical attributes can be altered based on how they are used in product development. This study aims to check how the gums or polymers play a crucial role in the sustain or control release of active ingredients in the gel formulation and find out the best gum among these which is play a crucial role in sustain release of APIs in gel. Gel formulations of various type of polymers (guar gum, xanthan gum, Carbopol) were prepared and evaluated for its pharmaceutical parameters like pH, viscosity, homogeneity, spread-ability. xanthan gum formulations have much better gelling behaviour, such as viscosity and muco-adhesiveness, than other gums that were chosen, according to the examination of the created gel formulations. So, it will produce more sustain release as compare to other gums.