Evaluation of Neutrophil/Lymphocyte, Lymphocyte/Monocyte and Lymphocyte/Platelet Ratios in Healthy Volunteers

ABSTRACT Objective: The aim of this study was to investigate the differences in neutrophil / lymphocyte, lymphocyte / monocyte, lymphocyte / platelet values between groups in different gender and age groups. Method: This study is a retrospective study. In January 2024, patients aged 18-60 years who applied to the family medicine outpatient clinic of Mengücek Gazi Training and Research Hospital and who did not have a known chronic disease were included in the study. In the study, Neutrophil, Lymphocyte, Monocyte, LDL, HDL, glucose, HBA1C, white blood cell (WBC), Platelet (PLT) results were examined. Results: A total of 165 subjects, 89.7% (n=148) male and 10.3% (n=17) female, were included in the study. The mean age of the participants was 38.96±10.63 years. The LDL value of the participants was 119.33±33, the HDL value was 44.52±8.48, the WBC value was 7.76±1.96, and the PLT value was 245±58.6. Participants' glucose values ranged from 72 to 319 and HBA1C levels ranged from 4.6 to 7.9. When the neutrophil/lymphocyte, lymphocyte/monocyte, lymphocyte/platelet ratios of the participants were evaluated, lymphocyte/platelet p=0.009 was found to be statistically significant. Conclusion: There are many studies evaluating lymphocyte/platelet, neutrophil/lymphocyte, lymphocyte/monocyte ratios and investigating their relationship with different diseases in the literature. However, due to the fact that whole blood parameters vary according to age, the differences between measurement methods affect the measurement results, and the differences between societies also have an effect, studies in the healthy human population for men and women in different age groups are very limited. It is important to conduct more studies in healthy human populations to examine the parameters that vary with age and to determine the reference intervals for our population.