The Correlation of Omega-3 Supplementation with CRP As Marker Inflammation in Autoimmune Diseases

Introduction: Omega-3 fatty acids are a type of polyunsaturated fatty acids (PUFAs) are regarded as anti-inflammatory lipids. The occurrence of diseases with an inflammatory aspect, including acute myocardial infarction, diabetes mellitus, autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA), psoriasis vulgaris, type 1 diabetes mellitus (T1DM), inflammatory bowel diseases (IBD) and systemic lupus erythematosus (SLE). Omega 3 can reduce inflammatory factor such as CRP (C- reactive protein) or hsCRP (High sensitive c-reactive protein). Objective: This systematic review aimed to investigate the beneficial effects of omega 3 fatty acid supplements which reduce inflammatory markers such as CRP in autoimmune populations. Materials and Methods: This systematic review was reported based on criteria from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A literature search was conducted with multiple electronic databases, such as PubMed, ScienceDirect, Google Scholar. The keywords used in electronic databases were described using Boolean operators. All the studies from these databases were stored in the authors’ library in Rayyan.ai. Results: Six studies were included in the qualitative synthesis. From six studies, 50% show omega-3 has a beneficial to reduce marker of inflammation such as CRP. But in the other case, 50% from the studies prove that omega-3 doesn’t have effect to reduce CRP serum levels in patient with autoimmune. Conclusion: This systematic review reveals that omega-3 supplementation for reducing CRP as marker inflammation in autoimmune disease has a potential. At the same time, this supplementation is associated with autoimmune recovery shown by the improvement of the CRP serum levels