Formulation and Evaluation of Fast Dissolving Film of Lisinopril

"An ultra-thin film containing an active ingredient that dissolves or disintegrates in the saliva at aremarkably fast rate, within few seconds without the aid of water or chewing," is the definition ofa fast-dissolving oral film (FDOF). The most up-to-date oral solid dosage form is fast-dissolving oral films (FDOFs), which provide more comfort and flexibility. It improves the absorption of active pharmaceutical ingredients (APIs) by dissolving them in saliva and allowing them to be swallowed without chewing or water. The oral mucosa is four to a thousand times more permeable than the epidermis, allowing for rapid drug absorption and rapid bioavailability. Formulated drug- opening foams (FDOFs) are made from hydrophilic polymers that dissolve rapidly in the mouth and release the medication into the bloodstream via the buccal mucosa. [1] A fast-dissolving drug delivery method is developed to enhance bioavailability of drugs with modest dosages and significant first-pass metabolism.