Anti-Cholinesterase Drugs and Its Effects in Alzheimer Disease, And Its Impacts Mainly Targeting Dementia in The Patients

Alzheimer’s disorder [AD] is a social and health care problem. The use of anti-cholinesterase has shown effect on decreasing dementia by increasing the levels of neurotransmitter Acetyl choline. We know that the cholinergic system plays an essential role in learning and memory. Some common anti-cholinesterase is donepezil, galantamine, rivastigmine. These drugs are the alkaloids which are isolated from natural sources such as physostigmine, have been recognized as acetyl and butrylcholinestrease inhibitors. Some other natural alkaloids belonging to steroidal and indole class (Amaryllidaceae, Buxaceae) have shown anti-enzymatic properties. These Anticholinesterase are also given combination, like donepezil and galantamine (DonGal) and berberine and tacrine (BerTac). This review article delves into the use of anticholinergic treatment in AD and also throws light on “Cholinergic Hypothesis”. However, there is a need of further studies on this class of drugs and better knowledge of biomarkers will further shed a light on the progression of the disease as well as action of the drug.