Sesamol: A Natural Phenolic Compound with Promising Therapeutic Potential

Sesamol is one of the naturally occurring phenolic compounds found primarily in sesame seeds and sesame oils. In recent years, it has drawn enormous scientific interest on account of its plethora of therapeutic attributes. Researchers have studied sesamol with a considerable degree of thoroughness to unveil potential health benefits, i.e., it can be considered an agent for the prevention and treatment of diseases. The primary aim of this review is to summarize and scrutinize the current literature on sesamol concerning its antioxidant, anti-inflammatory, neuroprotective, cardioprotective, anticancer, and other pharmacological effects. It examines mechanisms of action and highlight promising preclinical and clinical findings. In addition, it identifies some potential areas for further research. Strong evidence suggests that sesamol may be a potential therapeutic agent for a wide variety of diseases. However, to validate its efficacy and establish the optimal therapeutic dosages in humans, further comprehensive clinical trials are necessary. The present review attempts to provide an overview of the therapeutic landscape of sesamol and stimulate further investigation into its potential clinical applications.