Effect of Bone Marrow Aspirate Concentrate on Mixture of Fibrin Glue and Xenograft in Treatment of Critical Sized Periapical Bone Defects (Clinical and Radiographic Study)

ABSTRACT: Objective: The aim of this research was to evaluate bone regeneration capacity of a mixture ofFibrin glue and Xenogeneic bone graft versus a mixture of BMAC, Fibrin glue and Xenogeneic bone incritical sized periapical bone defects. Materials and methods: Sixteen patients randomly and equallydivided into two groups; Group I: eight patients with critical periapical bone defects were grafted by amixture of fibrin glue and xenograft. Group II: eight patients with critical periapical bone defects weregrafted by a mixture of BMAC, fibrin glue and xenograft. Assessment of pain was done on a VisualAnalogue Scale (VAS) immediate, 3 days and 1 week post-operatively. Radiographic evaluation: for thebone density, volumetric changes and defect dimensions measurement between study groups. Results: thehighest mean score on visual analogue scale was found in (Group I), while the lowest mean score was foundin (Group II). Group (II) experienced a significant positive change in defect dimensions, in bone density anddefect volume which increase by time in bone density over group (I) till the end of our follow up time whichis 6 months. Conclusion: MSCs present in BMAC promote bone regeneration and improve the density ofregenerated bone.Keywords: bone marrow aspirate concentrate, fibrin glue, critical bone defect, xenograft, bone regeneration