MORPHOMETRIC EFFECTS OF TANNIC ACID TREATMENTS FOLLOWING ETHANOL-INDUCED NEUROTOXICITY

Abstract: Background: Alcohol abuse induces dangerous health conditions. Tannic acids (TA) are plant-based derivatives gaining attention in scientific research due to its medicinal potentials. Aim: To evaluate the morphometric effects of TA treatments following ethanol-induced neurotoxicity in adult male Wistar rats. Methodology: Thirty six (36) adult male wistar rats (160g-240g) were assigned into six (6) groups (A to F) of 6 rats each. Group “A” (untreated negative control) received daily doses of distilled water at 6ml/kg/bwt while Group “B” (alcohol control group) received daily doses of 6g/kg/bwt of 40% ethanol only. Group “C, D and E” received daily doses of 6g/kg/bwt of 40% ethanol co-administrated with 200mg/kg/bwt, 100mg/kg/bwt and 50mg/kg/bwt of TA respectively. Group “F” (positive control group) received daily doses of 6g/kg/bwt of 40% ethanol co-administrated with 335mg/kg/bwt of Vitamin-E. All treatments were oral and lasted 14 days. Morphometric study involved estimating total body weights, brain weights and brain volumes. Body weights were recorded at two days intervals. Brain weights and volumes were measured after animal sacrifice under anaesthesia, 24 hours after final treatment via weighing and fluid displacement in calibrated test tubes. Following statistical analysis, p–value≤0.05 was considered as statistically significant. Result: High-doses of TA demonstrated significant impact on body weights in the early stages of ethanol-induced toxicity. Brain weights analysis displays no statistically significant differences in brain weights among the various groups. Brain volumes analysis showed statistically significant differences between groups suggesting that TA improves brain volume in response to ethanol-induced damage. Conclusion: TA demonstrated positive morphometric and neuroprotective potentials. Keywords: Tannic acid, Neuroprotective potentials, Neurotoxicity, morphometric, Wistar rats. Title: MORPHOMETRIC EFFECTS OF TANNIC ACID TREATMENTS FOLLOWING ETHANOL-INDUCED NEUROTOXICITY Author: Christian Chiemeka Ozor, Chike Anibeze International Journal of Novel Research in Healthcare and Nursing ISSN 2394-7330 Vol. 11, Issue 3, September 2024 - December 2024 Page No: 74-80 Novelty Journals Website: www.noveltyjournals.com Published Date: 24-December-2024 DOI: https://doi.org/10.5281/zenodo.14552478 Paper Download Link (Source) https://www.noveltyjournals.com/upload/paper/MORPHOMETRIC%20EFFECTS%20OF%20TANNIC-24122024-5.pdf