Formulation And Evaluation of Transdermal Patches of Doxycycline for Acne

The present study focuses on the formulation and evaluation of a transdermal patch containing doxycycline hyclate to provide sustained drug release and improve patient compliance. Patches were prepared using the solvent casting method with various polymers and permeation enhancers. The prepared formulations were evaluated for physicochemical properties, drug content, in-vitro drug release, and ex-vivo skin permeation using Franz diffusion cells. The optimized patch showed good mechanical strength, uniform drug content, controlled drug release, and effective skin permeation. Antibacterial activity was retained, and skin irritation studies confirmed safety. The study concludes that doxycycline transdermal patches offer a promising alternative to oral delivery with enhanced therapeutic benefits.