Synthesis, and biological evaluation of novel 2-(3-(5-cyano-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenoxy)acetic acid as potential in vivo anti-inflammatory agent

<p><a name="_Hlk101062992"></a><strong><span>Abstract:</span></strong><span> </span><span>Novel target compound, </span><span><span>2-(3-(5-cyano-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenoxy)acetic acid<em> </em></span><span>2</span><span>,<span> </span>was synthesized and evaluated for its anti-inflammatory activity using carrageenan-induced rat paw edema method in comparison with the selective COX-2 inhibitor, celecoxib. The results suggested that </span></span><span><span>compound <span>2 </span>proved </span><span>good potency with edema inhibition rates of 22.28 and 25.23% at the third and fifth hours, respectively.<span>  </span>More SAR study and optimization are warranted for compound<span> 2</span>, which has the potential to be employed as oral anti-inflammatory drugs.</span></span></p> <p><strong><span>Keywords</span></strong><strong><span>:</span></strong><span> Cyanopyridine; Anti-inflammatory; COX; Cyclooxygenase enzymes; Selective COX-2. </span></p> <p><strong><span>Title:</span></strong><span> Synthesis, and biological evaluation of novel 2-(3-(5-cyano-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenoxy)acetic acid as potential in vivo anti-inflammatory agent</span></p> <p><strong><span>Author:</span></strong><span> Alshimaa Kh. M. Ahmed, Mamdouh F. A. Mohamed, Eman A. M. Beshr</span></p> <p><strong><span>International Journal of Novel Research in Life Sciences<span>                                                    </span></span></strong></p> <p><strong><span>ISSN 2394-966X</span></strong></p> <p><strong><span>Vol. 12, Issue 2, March 2025 - April 2025</span></strong></p> <p><strong><span>Page No: 1-8</span></strong></p> <p><strong><span>Novelty Journals</span></strong></p> <p><strong><span>Website: www.noveltyjournals.com</span></strong></p> <p><strong><span>Published Date: 05-March-2025</span></strong></p> <p><strong><span>DOI: <a href="https://doi.org/10.5281/zenodo.14974196">https://doi.org/10.5281/zenodo.14974196</a></span></strong></p> <p><strong><span>Paper Download Link (Source)</span></strong></p> <p><strong><span><a href="https://www.noveltyjournals.com/upload/paper/Synthesis,%20and%20biological%20evaluation-05032025-2.pdf">https://www.noveltyjournals.com/upload/paper/Synthesis,%20and%20biological%20evaluation-05032025-2.pdf</a></span></strong></p>