Development and Assessment of Aceclofenac Gel-Based Topical Formula

Emulgel is an advanced drug delivery system that combines emulsion and gel for controlled topical release. Incorporating emulsion into a gel base enhances stability. Aceclofenac, a non-steroidal anti-inflammatory drug, is widely used for rheumatoid arthritis and osteoarthritis. This study aimed to develop and assess an aceclofenac emulgel to improve skin penetration compared to existing formulations. Five gelling agents—Carbopol 934, HPMC, Na CMC, and sodium alginate—were used. Drug release was tested via dialysis membrane, with all formulations exhibiting good physical properties. Among them, Carbopol 934 demonstrated the highest drug release efficiency.