Insilico Studies and Pharmacokinetic Properties of Anti-Alzheirmer's Disease Activities of Phytocompounds Derived from Lasianthera Africana

Abstract: Alzheimer’s disease (AD) is a devastating mental illness with an irreversible progressive brain disorder that slowly destroys memory skills and learning abilities. No treatments stop or reverse the progression of Alzheimer's disease, though some may temporarily improve symptoms. Hence, the limitations of these treatment methods necessitate the search for an alternative among the herbs available to man. Lasianthera africana locally known as "Editan" in Ibibio and Annang tribes of Southern Nigeria, has pharmacological benefits which includes; possession of analgesic, antipyretic, antimalarial, anti-ulcerogenic, antimicrobial, antidiabetic, anti-inflammatory, antioxidant, hepatoprotective and cardioprotective. Computational methods were used to study the binding interaction of 44 compounds derived from lasianthera africana against four target receptors (butyrylcholinesterase, beta secretase enzyme 1, protein tyrosine phosphate 1B and glycogen synthase kinase-3 beta) out of which, top four compounds (quercetin, epicatechin, oleandrin and quercetin 3-methyl ether) were selected based on their binding affinities. These four compounds in comparison with domepezil (reference drug) were subjected to drug-likeness screening to examine their physiochemical properties and admet analysis to examine their pharmacokinetical properties. These four ligands showed the best pharmacokinetic and physicochemical properties, including good absorption, distribution, metabolism, and excretion (ADMET) and admetSAR toxicity tests. It is demonstrated that quercetin, oleandrin, epicatechin and quercetin-3-methyl ether have promising therapeutic effect on Alzheirmer’s disease and Oleandrin exhibited a higher binding affinity and also a lower level of toxicity than the reference drug domepezil. Keywords: Alzheimer’s, phytocompounds, Lasianthera-africana, Admet, Domepezil. Title: Insilico Studies and Pharmacokinetic Properties of Anti-Alzheirmer’s Disease Activities of Phytocompounds Derived from Lasianthera Africana Author: Dearsly, Emmanuel Markus; Eze, Kingsley Chijioke; Chukwu, Constance Adaeze; Ofem, Lilian William International Journal of Novel Research in Life Sciences ISSN 2394-966X Vol. 11, Issue 5, September 2024 - October 2024 Page No: 58-73 Novelty Journals Website: www.noveltyjournals.com Published Date: 24-October-2024 DOI: https://doi.org/10.5281/zenodo.13986628 Paper Download Link (Source) https://www.noveltyjournals.com/upload/paper/Insilico%20Studies%20and%20Pharmacokinetic-24102024-3.pdf