Preparation And Evaluation of Herbal Transdermal Patch for Management of Varicose Vein

Vericose vein is condition that causes veins to bulge, swelling, twisting veins just below the skin’s surface most often in the leg and feet. They are also offered in topical treatments that provide relief from associated symptoms such as pain, swelling, and inflammation, but can be inconvenient to frequent application. In this study we developed a novel herbal transdermal patch for varicose vein management using Curcuma longa (turmeric) and Centella asiatica extracts. Anti-inflammatory and wound healing properties are attributed to curcuma longa and collagen synthesis with antioxidant activity to Centella asiatica. The extracted plant materials were authenticated using great care before extraction using Soxhlet and maceration yields 37% w/w and 23.12% w/w respectively. Curcuminoids in Curcuma longa extracts and triterpenoids in Centella asiatica extracts were confirmed by thin layer chromatography. Since both extracts have poor lipid solubility, transdermal patches were selected to increase skin penetration. Three HPMC based patch formulations (F1, F2, F3) were developed and these were subsequently investigated for stability and in vivo in rat. F1 and F2 were loaded with HPMC 50, and with F3 a mixture of HPMC 50 and HPMC 15 was used. Pharmaceutical characterization of formulations was performed by organoleptic evaluation, pH determination, folding endurance, thickness, drug uniformity, drug release, in vitro antioxidant activity, and in vitro anti inflammation activity. According to all parameters, HPMC polymer combination in Batch F3 had optimal performance, holding and releasing both extracts in a controlled manner. Further stability studies also demonstrated the suitability of F3 formulation. Hence, the F3 Formula is completed for the herbal transdermal patch for varicose vein management.