An Overview of Nanocochleates for Improving Oral Absorption of Antifungal Drugs Using a Phospolipid-Based Drug Delivery System

Nanaocochleate is a unique method of systemic and oral medication delivery. It is a novel lipid-based system that provides a unique technical platform suitable for the oral and systemic delivery of several substances with important medically therapeutic qualities, including genes, vaccine antigens, and pharmaceuticals. Hydrophobic macromolecules, tiny compounds with low oral bioavailability, and negatively or positively charged molecules are particularly well-suited for the technique of nanocochleate formulation. Clinically relevant, well-established medications that are now only provided by injection are being used in appropriate animal models to study the proof-of-principle of cochleate-mediated oral delivery of macromolecules and small molecule medicines. Phospholipids have overcome many of the challenges that have limited the therapeutic potential of conventional drug delivery methods. As formulation excipients, phospholipids have become more and more significant. This study intends to give a general review of the basic characteristics and uses of phospholipids in oral delivery systems, namely drug-phospholipid complexes and nanocochleates, in order to solve problems with the solubility and permeability of anti-fungal medications.