Analytical Techniques for Monitoring Atorvastatin in Pharmaceuticals: A Detailed Review

Atorvastatin, a lipid-regulating medication, is the world's best-selling drug. Therefore, it's crucial to monitor this medication. Because a sizable section of the populace can access it. Furthermore, the provision of high-quality medications depends on its quality control. The first stage in using medications sensibly may be the method of analysis. In light of this, an assessment of the analytical methods for pharmaceutical monitoring of atorvastatin that were available in the literature and official compendia was carried out. The representative papers used in this review were released between 2000 and 2024. HPLC stands out as one of the most popular analytical techniques for atorvastatin assessment, followed by HPLC coupled to MS, UV spectrophotometry and HPTLC. The matrix, stationary phase, mobile phase composition, detection wavelength, RF value, retention duration, detection limit, carrier gas, and flow rate are just a few of the characteristics that will be covered. Plasma is the most researched biological matrix, whereas tablets are the most researched pharmacological sample. Studies using pharmaceutical items based on atorvastatin are more prevalent in the literature than those involving biological components.