Synthesis And Biological Evaluation of Alkylated Indole Chalcone Derivatives as Antitubercular and Antimicrobial Agents

Infection with the bacteria Mycobacterium tuberculosis causes the disease tuberculosis. In Present research work we synthesized some N-alkylated indole chalcone derivatives and determined their biological activity against the H37Rv strain of Mycobacterium tuberculosis. Inside this library of compounds, (E)-1-(4-bromo-2-hydroxyphenyl)-3-(1-butyl-1H-indol-3-yl)prop-2-en-1-one (S1R8) and (E)-1-(4-bromo-2-hydroxyphenyl)-3-(1-pentyl-1H-indol-3-yl)prop-2-en-1-one (S1R16) displayed anti-tubercular activity with 04 µg/mL and 08 µg/mL MIC values, respectively. The in vitro antibacterial activity of all compounds was calculated against Gram-positive and Gram-negative bacteria. N-alkylated Indole Chalcone Derivatives were designed, synthesized and measured by ESI-MS and spectroscopic (FT-IR and 13CNMR) techniques.