Formulation, Evaluation, and Applications of Omeprazole Pellets IP: A Brief Review

Omeprazole, a widely used proton pump inhibitor, is highly effective in the treatment of acid-related gastrointestinal disorders such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger–Ellison syndrome. However, its acid-labile nature presents significant challenges for oral administration. Omeprazole Pellets formulated as per Indian Pharmacopoeia (IP) standards provide an effective solution through enteric coating and controlled-release strategies, ensuring drug stability and targeted intestinal delivery. This review provides a concise overview of the formulation components, manufacturing techniques (including extrusion–spheronization and fluid bed coating), and critical evaluation parameters such as particle size distribution, drug content, dissolution profile, enteric coating integrity, and stability. Additionally, it highlights the versatility of omeprazole pellets in various dosage forms—capsules, sachets, and orally disintegrating tablets—which enhance patient compliance, especially in pediatric and geriatric populations. Advances in polymer science and pelletization technology continue to improve the therapeutic performance and commercial relevance of omeprazole pellet formulations.