Assessment of Blood Parameters of Ethanoic Extract of Ripe and unripe Banana fruits in salt loaded Alcoholic and indomethacin induced Ulcerated Rats

This study aims to examine the Blood Parameters of Ethanoic Extract of Ripe and unripe Banana fruits in salt loaded, Alcoholic and indomethacin induced Ulcerative Rats. Eighty male wistar rats (weighing between 120-140g were grouped into 16 standard study groups of 5 animals each. Group A: Control group this group received food and water only. Group Bi: Ulcer induced by indometacine (NSAID) without treatment Group Bii: Ulcer (Alcohol) without treatment Group C: Received Sodium chloride orally for 2 weeks without treatment, Group Di: Received Sodium chloride orally all through the study (NaCl)+ Ulcer (NSAID) without treatment Group Dii: Received Sodium chloride orally all through the study (NaCl)+ Ulcer (Alcohol ) without treatment, each of the group were treated with unripe banana extract and ripe banana extract, all animals were sacrificed after exposure to chloroform. Blood was collected through cardiac puncture, placed in a lithium heparin sample bottles. Blood samples was spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes after which plasma was collected and stored frozen in plain sample bottles and was analyzed for Blood Parameters. Data obtained were analyzed as mean ± standard deviation using one way analysis of variance (ANOVA. Level of significance between groups was taken as p<0.05. The results of haematological tests of this present study showed that both ripe and unripe banana administration caused a significant (P< 0.05) increase in packed cell volume (PCV), haemoglogin concentration (Hb.), red blood cell count (RBC), MCV and MCH of blood in ulceration caused by both NSAID and alcohol. The findings of this present study also suggest that ulcer whether induced by NSAID or alcohol have the tendency of reducing the hemoglobin content of the blood.