Synthesis, Characterization and Antimicrobial Activity of Novel 2-Amino-4, 6-Dimethylpyrimidine and 2- Hydroxy-5- Nitrobenzaldehyde Schiff Base Ligand and Their Transition Metal Complexes

Abstract: The Novel Schiff base ligand has been synthesized by the condensation of 2-amino-4,6-dimethylpyrimidine and 2- hydroxy-5- nitrobenzaldehyde. Metal complexes of the Schiff base were prepared by the reaction of the Schiff base and Iron nitrate in ethanol solution. The complexes isolated, washed and dried. The Schiff base is pale yellow, while Cu(II) and Zn(II) complexes is light yellow.The synthesized compounds have been characterized by FT-IR, 1H-NMR and UV-Vis techniques for the ligands and FT-IR, UV-Vis, all reactions monitored by TLC, molar conductivity and magnetic susceptibility measurements for the corresponding complexes.The complexe is paramagnetic. The results of the molar conductivity measurements indicated that all complexes are non-electrolytes in (DMSO). An octahedral geometry for all the complexes of. The ligands are bidentate, (L₁) through phenolic (OH) and azomethine nitrogen. The ligand and its complexes were screened for their antifungal and antibacterial activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme, Aspergllus flavus and Escherichia coli, Salmonella typhi, Staphylococcus aureus, B. subtilis. The result indicated that the complexes exhibited good antifungal and antibacterial activities.