DYSREGULATION OF THE COMPLEMENT SYSTEM AND ITS IMPACT ON INFLAMMATORY PATHWAYS IN SYSTEMIC AUTOIMMUNE DISEASES: NEW THERAPEUTIC TARGETS

The complement system, a key component of innate immunity, plays a crucial role in inflammation and host defense. However, its dysregulation contributes to the pathogenesis of systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Recent studies highlight the role of complement overactivation in triggering inflammatory pathways, leading to tissue damage and immune dysregulation. This paper reviews the recent literature (2023) on complement system dysfunction in autoimmune diseases, elucidating its impact on inflammatory signaling. Furthermore, we discuss novel therapeutic strategies, including complement inhibitors, monoclonal antibodies, and small-molecule drugs targeting key complement proteins. Insights into these therapeutic targets offer promising avenues for modulating immune responses in autoimmune disorders.