Phytochemical Investigation and Antibacterial Activity of Gnidia glauca

The increase of antibiotic resistant is a substantial worldwide health challenge, and researchers are discovering various strategies to fight this issue, including potential role of plants. Medicinal plants have potential to play a significant role in the fight against antibiotic resistance. Gnidia glauca used in medicine for the treatment of cancer, wound, burns, snake bites. The plant was evaluated for phytochemical and antibacterial property. A fruit, flowers, leaves and stems of this plant are the reservoirs of naturally occurring phytochemical. Therefore, this study aimed at determining the phytochemicals and antibacterial activities of Gnidia glauca. Evaluation of phytochemical and antibacterial potential of Gnidia glauca leaves; ethanol and water were used for preparation of test extracts. The antibacterial activity was screened against Gram positive bacteria Bacillus megaterium, and Gram negative Pseudomonas aerogenosa, S.typhi, E.coliE.colidavis, S.paratyphi using streptomycin as reference drug .The phytochemical screening revealed that presence of alkaloids, flavonoids, steroids and tannin in aqueous extract. The ethanolic extract showed presence of alkaloids and flavonoids.Well diffusion method was used to assess the antibacterial effect of the extracts on micro-organisms. The ethanolic and aqueous extracts were active against all strains, when it is compared with standard streptomycin. Results concluded that Gnidia glauca having tremendous antibacterial potential.