Biochemical, Hematological, and Hepato-renal Study of Sendai Virus Infection in Wistar Rats

Abstract: Sendai virus (SeV) infection in Wistar rats was studied to evaluate its impact on hematological, biochemical, and hepato-renal parameters. The study aimed to understand the systemic effects of SeV infection beyond respiratory symptoms. Wistar rats were infected with SeV, and blood samples were collected at various time points. Hematological parameters, including red blood cell count, hemoglobin, hematocrit, platelet count, and white blood cell count, were analyzed. Biochemical parameters, such as liver enzymes (AST, ALT, ALP), total protein, total bilirubin, urea, and creatinine, were assessed to evaluate liver and kidney function. Results indicated significant alterations in hematological parameters, including reduced red blood cell count and hemoglobin, suggesting anemia. Liver function tests showed elevated levels of liver enzymes, decreased total protein, and increased bilirubin, indicating liver damage. Kidney function tests revealed increased levels of urea and creatinine, suggesting renal impairment. These findings highlight the systemic impact of SeV infection, extending beyond the respiratory tract to affect other vital organs. Understanding these effects is crucial for developing effective therapeutic interventions. Keywords: Sendai virus, Wistar rats, viral infection, Hematological parameters and hepato-renal parameters. Title: Biochemical, Hematological, and Hepato-renal Study of Sendai Virus Infection in Wistar Rats Author: Daodu, B. T., Onwukwe, C.D., Stanley, H.O., Akomah-Abadaike, O.N, Frank – Peterside, N International Journal of Life Sciences Research ISSN 2348-313X (Print), ISSN 2348-3148 (online) Vol. 12, Issue 4, October 2024 - December 2024 Page No: 54-63 Research Publish Journals Website: www.researchpublish.com Published Date: 21-December-2024 DOI: https://doi.org/10.5281/zenodo.14540412 Paper Download Link (Source) https://www.researchpublish.com/papers/biochemical-hematological-and-hepato-renal-study-of-sendai-virus-infection-in-wistar-rats