PROGNOSIS OF COMPLICATIONS IN TOXIC ALCOHOLIC LIVER LESIONS, TAKING INTO ACCOUNT BIOCHEMICAL PARAMETERS

Toxic liver damage can manifest itself in acute and chronic forms. Acute liver injury is characterized by necrosis and fatty degeneration of liver cells, hemodynamic disorders, edema and protein cell degeneration. It develops 2-3 days after exposure to the damaging agent and is accompanied by an increase in body temperature, weakness, loss of appetite, pain in the right hypochondrium, intense urine staining, jaundice of the sclera and skin. Hemorrhagic and hepatorenal syndromes may develop. In contrast to acute TG, the clinical picture of chronic toxic liver lesions is unexpressed, characterized by a relatively benign course without a tendency to progression [5; 6]. Interleukin-2 (IL-2) is a cytokine synthesized mainly by activated T-lymphocytes and plays a key role in regulating the immune response. In the context of alcoholic liver damage, IL-2 is involved in a complex cascade of immuno-inflammatory reactions accompanying damage to hepatocytes.