AQP4 gene single nucleotide polymorphisms rs2075575, rs162009 and rs335929 in Italian Parkinson's disease population

The association between three AQP4 gene SNPs (rs2075575, rs162009, rs335929) and Parkinson’s disease (PD) in an Italian cohort was investigated. Results show no significant correlation between these SNPs and PD risk. However, rs162009 was linked to reduced risk of REM sleep behavior disorder (RBD) in PD patients. Additionally, rs2075575 was associated with hallucinations in PD. These findings highlight the potential role of AQP4 in sleep disorders and PD symptoms, warranting further research.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-02-10
DOI
https://doi.org/10.5281/zenodo.14843944
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
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article

AQP4 gene single nucleotide polymorphisms rs2075575, rs162009 and rs335929 in Italian Parkinson's disease population

Zenodo (CERN European Organization for Nuclear Research)
Parkinson's Disease Mechanisms and Treatments
article

AQP4 gene single nucleotide polymorphisms rs2075575, rs162009 and rs335929 in Italian Parkinson's disease population

article en

Abstract

The association between three AQP4 gene SNPs (rs2075575, rs162009, rs335929) and Parkinson’s disease (PD) in an Italian cohort was investigated. Results show no significant correlation between these SNPs and PD risk. However, rs162009 was linked to reduced risk of REM sleep behavior disorder (RBD) in PD patients. Additionally, rs2075575 was associated with hallucinations in PD. These findings highlight the potential role of AQP4 in sleep disorders and PD symptoms, warranting further research.

Zenodo (CERN European Organization for Nuclear Research)
Don Carlo Gnocchi Foundation (IT)
Good health and well-being
Openalex Percentile: Top 43%
Parkinson's Disease Mechanisms and Treatments
DOIOpen Access PDFOpenAlex
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AQP4 gene single nucleotide polymorphisms rs2075575, rs162009 and rs335929 in Italian Parkinson's disease population · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS