Evaluation of combination study of Pterocarpus marsupium and tecoma stans for antidiabetic action

The present study investigates the anti-diabetic potential of Pterocarpus marsupium (heartwood extract) and Tecoma stans (leaf extract) in streptozotocin (STZ)-induced diabetic Wistar rats. Diabetes was induced via intraperitoneal injection of STZ (50 mg/kg). Rats were treated with individual extracts (200 mg/kg) and their combination for 21 days. Blood glucose, body weight, lipid profile, serum insulin, and histopathology of pancreatic tissue were evaluated. Both extracts significantly reduced fasting blood glucose and improved metabolic parameters. The combination group showed synergistic activity comparable to metformin. Findings support the potential of these plant extracts as complementary anti-diabetic agents.