Successful Pregnancy and Live Birth Following Hormone Replacement Treatment in a Patient with POI: A Case Report and Literature Review

Abstract Premature ovarian insufficiency (POI) is a condition characterized by at least four months of oligo/amenorrhea and an elevated serum follicle-stimulating hormone (FSH) level exceeding 25 IU/L on two separate occasions more than four weeks apart, with an onset before the age of 40. According to European Society of Human Reproduction and Embryology (ESHRE) guidelines, POI affects 1-2% of women of reproductive age, with 90% of cases classified as idiopathic. Approximately 25% of women with idiopathic POI may experience intermittent resumption of ovarian activity. This case report presents a 29-year-old POI patient with secondary infertility who successfully conceived and delivered a healthy baby following hormone replacement therapy (HRT).