Liquisolid Compacts: A Hybrid Approach to Enhance Drug Delivery

A unique and promising method for oral drug delivery is the Liquisolid technique, particularly useful for medications with limited or low aqueous solubility. This technique is especially effective for creating immediate-release and sustained-release formulations, as well as for highly permeable medications classified under BCS Class II. Currently, around 40 to 50 percent of medications on the market are water-insoluble, presenting challenges for the pharmaceutical industry in enhancing dosage forms' solubility and bioavailability. These challenges are effectively addressed through liquisolid compact technology. The inclusion of non-volatile solvents in the formulation ensures molecular dispersion, enhances medication wettability, and ultimately boosts solubility. This method increases the drug's surface area, improving both its bioavailability and aqueous solubility. To analyze this technique, pre-compression factors such as porosity, Carr's index, flow behavior, powder bed hydrophilicity, and saturation solubility are examined. The quality of the formulation is also monitored by assessing post-compression criteria, including homogeneity, weight variation, hardness, friability, wettability, and disintegration time. This technique incorporates coating materials like silica gel and disintegration agents, as well as carriers such as lactose, flour, and microcrystalline cellulose. The physicochemical properties of the formulation are characterized and evaluated using analytical techniques, including X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and Fourier-transform infrared spectroscopy (FTIR).