Preparation And Evaluation of Polyherbal Emulgel for The Management of Psoriasis

Psoriasis is a chronic autoimmune skin condition that causes rapid skin cell turnover, leading to the buildup of skin cells on the surface. This buildup results in thick, red patches covered with silvery scales, often appearing on the elbows, knees, scalp, and lower back. This study focuses on the formulation and evaluation of an herbal-based emulgel designed for psoriasis management, combining the stability and application ease of gels with the therapeutic benefits of emulsions. Utilizing Ayurvedic herbs, the formulation includes Curcuma longa, Emblica officinalis, and Aloe vera, chosen for their anti-inflammatory and antioxidant properties as a natural alternative to synthetic treatments for psoriasis. Curcuma longa and Aloe vera provide anti-inflammatory effects, while Emblica officinalis offers strong antioxidant activity. Extracts from these plants were obtained through Soxhlet extraction and maceration, yielding 34.76% for curcumin, 49.12% for Emblica officinalis, and 65% for Aloe vera. Five emulgel batches (F1-F5) were prepared using carbopol 934 as the gelling agent, oleic acid for the oil phase, and parabens as preservatives. Comprehensive characterization of each batch assessed key parameters such as pH, spreadability, viscosity, and drug release profile. Batch F5 exhibited the highest drug release rate, along with significant in vitro antioxidant and anti-inflammatory activities, marking it as the most promising formulation. F5’s therapeutic properties suggest its potential to effectively reduce symptoms associated with psoriasis, including redness, scaling, and inflammation, offering a non-invasive and natural approach to treatment. This herbal emulgel formulation demonstrates significant promise for improving quality of life for psoriasis patients and warrants further research, particularly in vivo studies, to substantiate its clinical efficacy and safety.