A Study on Coadministration of Phenylephrine with Oxytocin in the Prevention of Oxytocin-Induced Hypotension in Caesarean Section under Spinal Anaesthesia

Introduction: Oxytocin, used during Caesarean sections (CSs) under spinal anesthesia (SA) to reduce postpartum hemorrhage, can cause hypotension. To counteract this, phenylephrine, an α1-adrenergic agonist, is often coadministered. This study examines the efficacy and safety of combining phenylephrine with oxytocin to improve maternal hemodynamic stability during Caesarean sections. Methods: This prospective randomized study, approved by the ethics committee, was conducted at KIMS. Parturients with uncomplicated singleton pregnancies undergoing elective or emergency CSs were included. They were randomized into two groups receiving different phenylephrine doses with oxytocin. Parameters were monitored, and adverse effects were managed accordingly. Results: Statistically there was no significant difference in the mean duration of the surgery, extraction time of baby. In group A, 30 (37.5%) were identified with hypotension and it was 6.25% (5) in groups; statistically there was significant association. There were more episodes of hypertension in group A and statistically there was significant difference between groups. Conclusion: This study confirms that phenylephrine is significantly more effective than ephedrine in preventing hypotension during cesarean sections under spinal anesthesia. The findings align with existing literature, demonstrating phenylephrine’s superior ability to maintain maternal hemodynamic stability, thereby supporting its use in clinical practice for optimal outcomes.