Exploring the Anti-Tubercular Potential of Carbazole Chalcones: -An In Silico Approach

Tuberculosis is prominent disease which is fatal so the newer medicines is required to face the drug resistance. Chalcone based derivatives being potential source for wide spectrum of ant proliferative, antibacterial, antimalarial pharmacological properties The designed compounds were screened using SWISS ADME and Osiris Property Explorer. The compound12,13,14,15,17 and 20 showed promising character for further research. The docking study using PyRx 0.8 also showed the commendable binding affinity more than 9.9 Kcal/moll comparing to standard Isoniazid 6.5Kcal/mol in InhA protein PDB ID :4TRO.