Compare Pupil Size in Migraine Patients with Photophobia versus Normal Subjects and Correlation of the Pupil Size to Severity of Headache

This study suggests that patients with migraines and photophobia have significantly larger pupil sizes compared to normal subjects without headaches. The findings indicate a correlation between pupil size and the severity of migraine disability as measured by the Migraine Disability Assessment (MIDAS) test. Migraine patients with photophobia had a mean pupil size of 4.89 mm, while normal subjects had a mean of 3.8 mm. The difference was statistically significant. Based on MIDAS grades, patients with more severe disability (Grade 4) had the largest pupil size, averaging 5.6 mm. This indicates a potential link between larger pupil size and greater migraine severity. The study concludes that larger pupil size could potentially trigger migraine attacks, and the severity of migraine symptoms increases as pupil size increases.