Effect of colistin injury on aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transferase activities in ovariectomized rats

Colistin is an antibiotic with a dose-limiting side effect when used against multidrug-resistant gram-negative pathogens. The aim of this study was to investigate the effect of colistin on aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) activities in ovariectomized rats. Group I was the control group, Group II was ovariectomized only and Group III was ovariectomized and colistin administered. Colistin administration caused damage in ovariectomized rats. AST, ALT and GGT activities were higher (p<0.001) in Group III compared to the other groups. The increase in AST, ALT and GGT activities due to 73 mg/kg colistin application is an indicator of damage. For this reason, considering the effects found in the study, administration of colistin at a lower dose and duration can be considered as an alternative medicine option.