Pharmaceutical Evaluation of Physalis peruviana from Far Western Nepal

This study provides valuable information regarding phytochemical screening and antimicrobial activities of ripen fruits of Physalis peruviana from darchula district of Far Western region of Nepal. Physalis peruviana fruits contain many pharmaceutically important secondary metabolites such as withaphysalins, physalins, phytosterols, polyphenols, flavonoids, proteins, aminoacids, saponins, tannins, terpenoids, vitamins, carbohydrates, carotenoids, vitamin C, vitamin E, essential fatty acids and minerals which are responsible for wide range of antibacterial effects. The fruits are rich in ash, fibres and moisture content. The crude extract of the Physalis peruviana fruits was analysed by GC-MS as compared to reference database. The antimicrobial activity against gram positive and gram negative bacteria viz, Bacillus subtilis, Pseudomonas syringae, Escherichia coli, and Salmonella shigella were evaluated. The extract has shown excellent antibacterial potential by measuring zone of inhibition and minimum inhibitory concentration (MIC) along with minimum bactericidal concentration (MBC) and IC50 value.