Synthesis ,Characterization And Biological Evaluation Of Novel 1,3,4-Thiadiazole Derivatives

Purpose: In the present study novel compounds of 1,3,4-Thiadiazole derivatives were synthesized because they are constitutes an important class of compounds for new drug development these are synthesized by using optimised chemical reactions Methods: All these newly synthesized compounds were screened for their in vitro antimicrobial activity by an agar plate diffusion method,antidiabetic activity by ex-vivo everted intestinal sac method. Results: The structures of all the newly synthesized compounds were characterized by their IR, HNMR, mass spectral studies and elemental analysis. In Antibacterial activity FTB-5 and FTB-3 were effective against Bacillus subtilis and Streptococcus aureus. FTA-1 and FTB-6 is found have moderate activity against both Bacillus subtilis and Streptococcus aureus and FTB-1,FTB-2,FTB-4 and FTA-2 showed activity against Bacillus subtilis.In Antifungal activity FTB-1, FTB-5, FTA-1, FTB-3 were effective against Asregillus niger ,FTB-6, FTA-2 is found to have moderate activity.In Antidiabetic activity FTB-1 and FTA-1 were shown more significant activity when compared to standard of 1mg/ml conc. conclusion: The synthesized compounds FTB-3 having chlorine group in benzene ring and FTB-5 having acetoxy group in benzene ring exhibited good antimirobial activity,FTB-1 having both amine and chlorine groups in benzene ring and FTA-1having nitro group in benzene ring exhibited good antidiabetic activity .