The Role of Statin in Stroke Management

Background: Stroke is an important cause of disability and death globally. Statins, primarily used to lower cholesterol, have demonstrated potential in reducing stroke incidence and recurrence. This study evaluates the effectiveness of statins in preventing stroke and managing stroke recurrence in high-risk individuals. Methods: A prospective study was conducted at Darbhanga Medical College over one year with 100 patients, either at high risk of stroke or with a history of stroke or transient ischemic attack (TIA). Patients received statins, and their cholesterol levels, incidence of stroke recurrence, and any adverse effects were monitored and analyzed. Results: Statin therapy significantly lowered total and LDL cholesterol levels from baseline, with total cholesterol reduced from 240 mg/dL to 185 mg/dL and LDL from 160 mg/dL to 105 mg/dL by the end of the study. Stroke recurrence was observed in only 8% of patients, while 92% remained stroke-free. Adverse effects, primarily muscle pain (15%) and liver abnormalities (5%), were minimal and manageable. Conclusion: Statins proved effective in reducing cholesterol and stroke recurrence, with a favorable risk-benefit profile. These findings favour the continued use of statins in high-risk stroke patients, highlighting the need for personalized dosages to balance efficacy and side effects.