Formulation And Evaluation Of Floating Matrix Tablets For Anti Gastric Drug

Prolonged usage of proton pump inhibitors (PPIs) has been linked to a higher likelihood of specific health problems, such as bone fractures and deficits in essential nutrients. The attention on floating systems led to a decrease in synthetic polymers by effectively using natural polymers, which possess desired characteristics such as biocompatibility and biodegradation features derived from HPMC. It is even feasible to alter its properties by adjusting the level of deacetylation in order to get reduced density, swellability, and enhance its suitability for drug delivery by floating methods. The present work successfully achieved its desired goal by developing a floating drug delivery system for Omeprazole. The experimental section yielded satisfactory results, which are summarised below. The floating tablets were synthesised using the wet granulation method. The characteristics assessed for granules included bulk density, tap density, compressibility index, Hausner's ratio, and angle of repose. The evaluated flow parameters and derived attributes for all 9 formulations were shown to be within acceptable ranges, indicating favorable flow characteristics. The physicochemical properties of floating tablets of all formulations were investigated by measuring parameters including thickness, diameter, hardness, friability, weight change, and drug content. Observed average values and variances for the above parameters were within the specified limits. The floating characteristics, including floating lag time and total floating time, were measured for all available tablets, revealing that all the tablets produced exhibited favorable floating features. The presence of the gas producing agents NaHCO3 and citric acid may be the cause of this observed phenomenon. The buoyant properties of the floating tablets were determined by the swelling of hydrocolloid particles on the surface upon contact with the stomach fluid, as well as the existence of empty space or porosity in the dry centre of the tablet. An In vitro drug release laboratory investigation showed that the manufactured tablet F1 exhibited the highest percentage of cumulative drug release after 12 minutes. This might be attributed to the presence of HPMC K100. The stability tests were carried out following the ICH recommended protocols for duration of 6 months. These findings indicate that HPMC with Omeprazole as floating tablets exhibit similar floating and drug release properties, suggesting that it may have moderate clinical effectiveness.