PHARMACOLOGICAL EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF AQUEOUS AND ALCOHOLIC EXTRACTS OF AEGLE MARMELOS ROOT

The aqueous and alcoholic extract of given herbal powder showed the presence of alkaloids, carbohydrates, phenols, flavonoids, glycosides, saponins and terpens. The aqueous and alcoholic extract of given herbal powder at two dose levels 200 mg/kg and 400 mg/kg body weight administered orally for five days to the CCl4 challenged rats produced significant reversal of biochemical changes in liver and serum intoxicated by CCl4 treatment. The aqueous and alcoholic extracts prevented wide range of tissue injury in CCl4 challenged rats as evidenced by significant reduction in GOT, GPT, ALP, Total bilirubin and LPO levels. The aqueous and alcoholic extracts treated animals produced significant increase in the levels of total protein, GPx, GST, GRD, SOD and catalase in animals challenged with CCl4.The present study has made an attempt to demonstrate the hepatoprotective activity of aqueous and alcoholic extracts of herbal powder containing in protecting the CCl4 induced hepatocellular damage. As the aqueous and alcoholic extracts possess various active constituents a need arise for further phytochemical and biochemical studies for identifying the constituent responsible for hepatoprotective property, thereby revealing the hepatoprotective role of aqueous and alcoholic extracts of in the given herbal powder.