FORMULATION AND EVALUATION OF BILAYER TABLET OF NATEGLINIDE

The main objective of research work is to develop a bilayer tablet of Nateglinide, in which one layer is immediate layer for immediate action and second layer is the sustain release layer for maintaining the dose of the drug. Preformulation study was performing for various parameters like melting point, Bulk density, Tapped density. Carr’s index, Housner ratio etc. Bilayer tablets were prepared in two stages by using Crosspovidone different viscosity grades of hydroxy propyl methyl cellulose (HPMC) viz., K4M and K100M. The prepared Bilayer tablets were evaluated for hardness, bulk density, tapped density, friability, uniformity of weight, drug content, in vitro dissolution and drug-polymer interaction. Immediate layer drug content result was found to be 4.89±0.152 kg/cm2 and 99.26 ±1.42. On the basis of disintegration and dissolution studies, I 3 was found to be superior amongst them which show disintegration time 28 ±2.10 second and 98% drug release and sustain layer drug content result was found for S3 5.4 ±0.31 kg/cm2and 97.86 ±0.90, for S6 5.5±0.52 kg/cm2 and 97.55±1.59 and for S9 5.5±0.15 kg/cm2 and 98.25±1.53 respectively, but for further refinement the batches were subjected for dissolution studies. On the basis of dissolution studies, the S9 batch was found to be superior amongst them which show 95 % drug release in 24 hours.