CRP Levels in PCOS-IR Rat Models (Rattus norvegicus) After Administration of Moringa oleifera Extract

Polycystic Ovarian Syndrome (PCOS) is a metabolic syndrome affecting women’sreproductive health. PCOS is diagnosed using Rotterdam Criteria, and is oftenassociated with insulin resistance. PCOS with insulin resistance (PCOS-IR) can bothinduce inflammation, in which the inflammation itself can worsen PCOS-IR. Moringaoleifera is a plant tested for its anti-inflammatory and anti-oxidant properties frompytochemicals that can be found in it. Aim: This research aims to study the effect ofMoringa oleifera leaf extract administration to PCOS-IR rat models towards levels ofC-reactive protein (CRP), a widely known biomarker of inflammation. Method:Female Wistar rats were divided into 3 groups (n=10): normal rats, PCOS-IR rats andPCOS-IR rats administered with 500 mg/kg Moringa oleifera leaf extract. PCOS ratmodel is created by injecting 1 mg / 100 gr testosterone proprionate for 21 days, andanother 21 days for Moringa oleifera leaf extract administration. Blood is thencollected and tested for CRP, and data collected will be statistically processed. Results:The PCOS-IR group showed increase in CRP level compared to control group, and theMoringa oleifera treated group showed significantly lower CRP level compared toPCOS group. The CRP level in Moringa oleifera treated group comes near to that ofcontrol group. Conclusion: Consumption of Moringa oleifera leaves can reduceinflammation in PCOS-IR shown by significant decrease of CRP levels.