Evaluation of the Relationship Between Vitamin D Levels and Glycemic Parameters in Prediabetic Individuals

ABSTRACT Objective: Prediabetic condition is a precursor clinical picture that poses a significant risk for the development of diabetes. Early diagnosis and treatment are crucial for preventing micro and macro complications. Numerous studies have been conducted to explore the relationship between Vitamin D and the development of diabetes, attempting to clarify this connection. We planned this study to examine the relationship between Vitamin D and glycemic parameters in prediabetic individuals and to lay the groundwork for future research in this direction. Method: Our study included 192 patients aged 24‐65 who presented to internal medicine clinics. The study retrospectively examined 93 prediabetic individuals and 99 healthy individuals without any diseases, drug use, Vitamin D supplementation, or any other significant characteristics. The selected patients' demographic data, fasting glucose levels, HbA1C, insulin, HOMA-IR, 25(OH)D vitamin, calcium, and albumin levels were analyzed using chromatography equipment, HPLC method. The Chi-Square test was used to determine the differences in categorical data between groups. The level of statistical significance was set at p<0.05. Results: The mean age was 53.18±12.71 in the prediabetic group and 42.44±14.72 in the control group. No statistically significant difference was observed in gender distribution between the two groups (p=0.9072). When comparing Vitamin D levels between the two groups, it was found to be 14.62±6.87 ng/mL in the prediabetic group and 17.53±11.02 ng/mL in the control group, which was statistically significant (p=0.029). Conclusion: Our study found a significant difference in Vitamin D levels between prediabetic individuals and healthy individuals with normoglycemic progression. Observational studies suggest a significant relationship between Vitamin D and diabetes mellitus, and similar findings are observed in prediabetic individuals. We believe that Vitamin D supplementation in the prediabetic population could have significant effects on public health and glucose metabolism. Keyswords: Prediabetes, Vitamin D, Glycemic Parameters.