MENSTRUAL FUNCTION IN WOMEN WITH DIAGNOSED THYROID PATHOLOGY AFTER COVID-19

The aim. To study the peculiarities of menstrual function in women of reproductive age, in whom various pathologies of the thyroid gland were detected after suffering from COVID-19. Materials and Methods. A study was conducted on 60 women with menstrual dysfunction and diagnosed thyroid pathology following COVID-19 infection within the last year. The average age was 27.1±0.7 years. General clinical, laboratory, and gynecological examinations were performed, including thyroid ultrasound, and measurements of TSH, free T4, free T3, anti-TPO antibodies, estradiol, and progesterone levels. Results. Thyroid pathology was detected in 43 women (71.7%): subacute thyroiditis in 16 (11.6%), AIT in 38 (88.4%). Menstrual dysfunction in these patients (n=43) included opsomenorrhoea (25.6%), secondary amenorrhea (23.3%), metrorrhagia (16.3%), hypermenorrhea (11.6%), algodismenorrhea (10%), and menorrhagia (14%). Hormonal thyroid profile showed 23.3% with euthyroidism, 69.7% with subclinical hypothyroidism, and 7% with subclinical hyperthyroidism. For subclinical hypothyroidism (n=30), opsomenorrhoea was present in 33.3%, secondary amenorrhea in 26.7%, metrorrhagia in 13.3%, hypermenorrhea in 6.7%, algodismenorrhea in 6.7%, and menorrhagia in 13.3%. For euthyroid status (n=10), opsomenorrhoea was present in 10%, secondary amenorrhea in 20%, metrorrhagia in 10%, hypermenorrhea in 30%, algodismenorrhea in 10%, and menorrhagia in 20%. Hyperthyroidism on the background of AIT was found in 3 women, with metrorrhagia in 2 and algodysmenorrhea in 1. Conclusions. Menstrual dysfunction in women after COVID-19 is a result of thyroid pathology caused by the virus. The main types of menstrual disorders are opsomenorrhoea (25.6%), secondary amenorrhoea (23.3%), metrorrhagia (16.3%), hypermenorrhoea (16.3%), algomenorrhoea (16.3%), and menorrhagia (16.3%). The clinical course varied with thyroid function: subclinical hypothyroidism led to opsomenorrhoea (33.3%) and secondary amenorrhoea (26.7%); euthyroid state resulted in hypermenorrhoea (30%) and secondary amenorrhoea (20%); hyperthyroidism caused metrorrhagia. Early detection and treatment of thyroid disorders can improve women's reproductive health.