Efficacy of Carica Papaya Leaf Extract in Treating Dengue-Induced Thrombocytopenia: A Review of Clinical and Preclinical Studies

However, dengue fever is a common world-wide public health problem associated with severe thrombocytopenia and haemorrhagic complications. Currently, there are no specific antiviral or platelet stimulating treatments, which are described as the current treatments, and top of those are supportive care (fluid therapy, platelet transfusions). The betterment of CPLE has recently been being discussed more for the dengue patients’ platelet recovery, as they independently increase in efficiency. Phytochemical examination of CPLE showed its immunomodulatory, antioxidants and the anti-inflammatory properties. It also emerged from preclinical studies that CPLE drives megakaryocyte growth driven thrombocytopaenia and platelet production as well as inflammatory modulation. In addition, CPLE exhibits an anti-viral activity against the virus, dengue virus. From the observational and controlled point of view, clinical trials that enhance tremendously increase of the values of platelet counts, accelerate the time of recovery, maintain the haematocrits values stable, as well as reduce the duration of hospital stay, without any other cohabiting side effects are proposed. However clinical applicability is threatened by variability in study design, preparation methodology, and that of large scale randomized controlled trials. Future work includes trials in multiple canters, standard dose, optimal combination regimens and approval by the regulatory authorities. CPLE was further validated as a safe and low cost of adjunct therapy to the dengue disease associated thrombocytopenia for the area endemic for the diseases and will thus reduce the disease burden.